Depression and Weird Dreams Treato found 1,991 discussions about Weird Dreams and Depression on the web. Symptoms and conditions also mentioned with Depression in patients' discussions If you have clinical depression, you're probably familiar with the wee hours of the morning. Depression is known to cause sleep disturbances such as insomnia, early morning awakenings, and bad dreams or nightmares. Wellbutrin is for depression, and can be stimulating and thus exacerbate anxiety in those who suffer from anxiety. Buspar is said to do nothing much, so I would guess the wellbutrin is more to blame. Day 9, I hope to get more than just weird dreams with this stuff. I don't really care to be loosing sleep at night. Find information about common, infrequent and rare side effects of Wellbutrin XL Oral. I take Wellbutrin and I have not experiencced those kinds of dreams. However, I did start out taking another anti-depressant and then added Wellbutrin to it, so that could be part of the difference. However, I did start out taking another anti-depressant and then added Wellbutrin to it, so that could be part of the difference. Wellbutrin gave me nightmares and headaches and wasn't strong snuff. Setraline (I think that's how it is spelled) made me edgy and nervous, celexa worked but after awhile it wasn't strong enuff. Hello orangewhite26. The one possible solution I think of is to reduce your wellbutrin dose to maybe 225mg? I had some vivid dreams when I was on wellbutrin before but it wasn't an ongoing problem for me. Wellbutrin has given me much more intense dreams -- not unpleasant, but as you say, intricately plotted and very detailed, more like movies than regular dreams. I also find myself remembering them every morning. I also take melatonin, which heightens the effect.